The present study investigated the relationship between Greek adolescents’ mental health and their psychological separation-individuation from their parents. Twohundred and forty adolescents, 15-17 years old, were administered Achenbach's Youth Self Report and the Psychological Separation Inventory. Higher levels of conflictuel independence, i.e., freedom from dependent relationships with parents characterized by excessive guilt, anxiety, mistrust, inhibition, and anger were significantly associated with adolescents’ better academic performance and social competence, as well as with fewer internalizing and externalizing behavior problems. Academic competence was associated with lower levels of adolescents’ functional independence from mother. Internalizing behavior problems were found to be related to less emotional independence from parents